Professor Manas graduated from Witwatersrand University in Johannesburg 1980 and completed his surgical training at Groote Schuur Hospital in Cape Town, South Africa.
He completed two fellowships at Johns Hopkins, Baltimore and Paul-Brousse, Paris. He was the recipient of the CJ Adams/Sandoz Traveling Fellowship to the UK in 1993 and joined the NHS (Freeman Hospital - Newcastle upon Tyne) in 1994.
He attained a personal chair in Transplant and HPB Surgery at Newcastle University in 2007 and has been instrumental in successfully developing a super-regionally funded transplant program in the Northeast of England as well as establishing an HPB and Abdominal Sarcoma cancer service for the region.
He established the first integrated Transplant Institute in the UK and was appointed as the first Director.
He was the President of the British Transplantation Society and is the current member of the council and past Chair of the British Liver Transplant Group (BLTG). He was previously deputy chair of the NHSBT Liver Advisory Group as well as NHS England Hepato-Pancreatico-biliary Clinical Reference Group.
Derek has many research interests including novel markers for early detection of hepatocellular (HCC) cancer and cholangiocarcinoma, ablation techniques for treating liver tumours, liver transplantation for cancer, radio-embolization in the management of HCC and colorectal liver metastases and irreversible electroporation (IRE) for the treatment of pancreatic cancer.
He has over 350 peer review publications, 8 book chapters and co-edited 2 books on liver tumours. He is currently an examiner for the Royal College of Surgeons and European Exam board and a University external examiner for postgraduate degrees. He is a an associate editor of Transplantology and a regular reviewer for numerous journals including - British Journal of Surgery, American Journal Surgery, European Journal of Surgical Oncology and American Journal Transplantation.